In Mali, the Learning Hub has built a collaborative knowledge translation system anchored by the Collaborative Intelligence Platform—a tool for sharing evidence, coordinating stakeholders, and guiding decision-making. Through co-creation with partners such as the Centre National d'immunisation, the World Health Organization, and the UNICEF, the Learning Hub developed targeted learning products and embedded evidence into national planning. This approach led to policy shifts, including informing Mali’s conflict-zone vaccination strategy and budgeted plans to compensate volunteer vaccinators. The Spotlight highlights how structured knowledge translation processes, stakeholder training, and digital platforms are driving systemic change in Mali’s immunization landscape.