MRITE and the Ministry of Health and Family Welfare in India developed a monitoring, evaluation, and learning system for COVID-19 vaccination activities in 18 states across India. This case study outlines the data management flow, data process and systems, and the corresponding benefits, challenges, and opportunities, and summarizes key lessons. Although focused on COVID-19, it provides an example of data use to inform program implementation, as well as the generation and uptake of knowledge. These strategies could be adopted and adapted to the zero-dose context.