This study aimed to identify barriers and context-appropriate solutions by engaging deeply with caregivers, community members, health workers, and other health system actors through participatory action research, intersectionality, and human-centered design lenses. In addition to providing insight into the multi-faceted barriers that caregivers of zero-dose children experience, this article shows how non-traditional MEL methods, such as human-centered design and an intersectionality lens, can be used to better understand the drivers of zero-dose and inform pro-equity strategies to identify and reach zero-dose children and their communities. It also provides recommendations on how human-centered design and intersectionality approaches can be incorporated into immunization research and program planning, management, and implementation.