This guide, developed in conjunction with the Ethiopian Ministry of Health, is intended for staff at the primary health care unity level. It provides step-by-step guidance on how the Reaching Every District (RED) approach should be implemented within health centers and health posts, including a detailed description of tasks that should be carried for the management and delivery of immunization services, as well as relevant tools. Specifically, it breaks down tasks by those that need to be completed every year, every quarter, every month, every vaccination session, and as needed.